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Thats my very generalized explanation

Smoking makes joint replacement recovery harder If you are a smoker and think you need a joint replacement, our surgeons will recommend that you quit smoking before you have surgery

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ACKNOWLEDGMENTS Professor Hennekens has no financial or proprietary interest in the subject matter of this article but discloses that he serves as an independent scientist in an advisory role to investigators and sponsors as chair of data monitoring committees for Amgen and UBC, to the Collaborative Institutional Training Initiative, the United States Food and Drug Administration as a special government employee, and UpToDate

CONCLUSIONS Based on untargeted metabolomics and bioinformatics analyses, 1150 metabolites were identified to be differentially expressed between the HN and LN groups, such as cotinine, NNAL-N-glucuronide, and 11-dehydrothromboxane-B2